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Article

An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.

The American journal of pathology - 1 Aug 2011

Manji Shehnaaz S M, Miller Kerry A, Williams Louise H, Andreasen Lotte, Siboe Maria, Rose Elizabeth, Bahlo Melanie, Kuiper Michael, Dahl Hans-Henrik M

Abstract excerpt

Mutations in the human cadherin 23 (CDH23) gene cause deafness, neurosensory, autosomal recessive 12 (DFNB12) nonsyndromic hearing loss or Usher syndrome, type 1D (characterized by hearing impairment, vestibular dysfunction, and visual impairment). Reported waltzer mouse strains each harbor a Cdh23-null mutation and present with hearing loss and vestibular dysfunction. Two additional Cdh23 mouse mutants, salsa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21689626
DOI: 10.1016/j.ajpath.2011.04.002
PMCID: PMC3157152

Genes

CDH23

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.PMID 21689626Read ↗

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Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.Semantic proximity Read ↗

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A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.Semantic proximity Read ↗

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Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23.Semantic proximity Read ↗

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