Article
A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging.
PloS one - 1 Jan 2013
Sheykholeslami Kianoush, Thimmappa Vikrum, Nava Casey, Bai Xiaohui, Yu Heping, Zheng Tihua, Zhang Zhaoqiang, Li Sheng Li, Liu Shuqing, Zheng Qing Yin
Abstract excerpt
Atoh1 is a transcription factor that regulates neural development in multiple tissues and is conserved among species. Prior mouse models of Atoh1, though effective and important in the evolution of our understanding of the gene, have been limited by perinatal lethality. Here we describe a novel point mutation of Atoh1 (designated Atoh1(trhl) ) underlying a phenotype of trembling gait and hearing loss. Histology...
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