Article

Predicting High Confidence ctDNA Somatic Variants with Ensemble Machine Learning Models

2025-01-24

Abstract excerpt

<title>Abstract</title> <p>Circulating tumour DNA (ctDNA) is a minimally invasive cancer biomarker that can be used to inform treatment of cancer patients. The utility of ctDNA as a cancer biomarker depends on the ability to accurately detect somatic variants associated with cancer. Accurate somatic variant detection in circulating cell free DNA (cfDNA) NGS data requires filtering strategies to remove germline va...

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Literature Corpus work: d1487e7c-2eeb-5379-bd13-6db33e0466df
DOI: 10.21203/rs.3.rs-5735554/v1

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