Article

An artificial intelligence-based model for prediction of Clonal Hematopoiesis mutants in cell-free DNA samples

2024-12-16

Abstract excerpt

Circulating tumor DNA is a critical biomarker in cancer diagnostics, but its accurate interpretation requires careful consideration of clonal hematopoiesis (CH), which can contribute to variants in cell-free DNA and potentially obscure true tumor-derived signals. Accurate detection of somatic variants of CH origin in plasma samples remains challenging in the absence of matched white blood cells sequencing. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 339567c2-07a8-5cb4-9e41-e554df5bb5c3
DOI: 10.1101/2024.12.11.627785

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An artificial intelligence-based model for prediction of Clonal Hematopoiesis mutants in cell-free DNA samplesDOI 10.1101/2024.12.11.627785Read

An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samplesSemantic proximity Read

plasmaCHORD: A Machine Learning Approach to Distinguish Clonal Hematopoiesis-Derived Variants in Liquid Biopsies from Patients with Solid Tumors.Semantic proximity Read

Unified somatic calling and machine learning-based classification enhance the discovery of clonal hematopoiesis of indeterminate potentialSemantic proximity Read

Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers.Semantic proximity Read

Machine learning framework for predicting the presence of high-risk clonal haematopoiesis using complete blood count data: a population-based study of 431,531 UK Biobank participantsSemantic proximity Read

Clonal hematopoiesis detection in cancer patients using cell free DNA sequencingSemantic proximity Read

Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsySemantic proximity Read

How low can you go?: Methodologic considerations in clonal hematopoiesis variant calling.Semantic proximity Read

Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypesSemantic proximity Read

Detection and Interpretation of Clonal Hematopoiesis Variants during Routine Solid Tumor Next-Generation Sequencing: A Single-Institution Experience.Semantic proximity Read

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.Semantic proximity Read

Characterization of Plasma Cell-Free DNA Variants as of Tumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer PatientsSemantic proximity Read