Article
Sensitive detection of tumor mutations from blood and its application to immunotherapy prognosis.
Nature communications - 7 Jul 2021
Li Shuo, Noor Zorawar S, Zeng Weihua, Stackpole Mary L, Ni Xiaohui, Zhou Yonggang, Yuan Zuyang, Wong Wing Hung, Agopian Vatche G, Dubinett Steven M, Alber Frank, Li Wenyuan, Garon Edward B, Zhou Xianghong Jasmine
Abstract excerpt
Cell-free DNA (cfDNA) is attractive for many applications, including detecting cancer, identifying the tissue of origin, and monitoring. A fundamental task underlying these applications is SNV calling from cfDNA, which is hindered by the very low tumor content. Thus sensitive and accurate detection of low-frequency mutations (<5%) remains challenging for existing SNV callers. Here we present cfSNV, a method...
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