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An artificial intelligence-based model for prediction of clonal hematopoiesis variants in cell-free DNA samples

20 May 2025

Abstract excerpt

Circulating tumor DNA is a critical biomarker in cancer diagnostics, but its accurate interpretation requires careful consideration of clonal hematopoiesis (CH), which can contribute to variants in cell-free DNA and potentially obscure true tumor-derived signals. Accurate detection of somatic variants of CH origin in plasma samples remains challenging in the absence of matched white blood cells sequencing. Here...

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PMID: 40394286
DOI: 10.1038/s41698-025-00921-w

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