Article

Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels

2023-04-06

Abstract excerpt

Next generation sequencing of cell-free DNA (cfDNA) is a promising method for treatment monitoring and therapy selection in metastatic breast cancer (MBC). However, distinguishing tumor-specific variants from sequencing artefacts and germline variation with low false discovery rate is challenging when using large targeted sequencing panels covering many tumor suppressor genes. To address this, we built a machine l...

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Literature Corpus work: 0af2dc94-a7a4-5935-bebb-72a35faad19e
DOI: 10.21203/rs.3.rs-2742846/v1

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