Article
The potential of the riboSNitch in personalized medicine.
Wiley interdisciplinary reviews. RNA - 1 Jan 2000
Solem Amanda C, Halvorsen Matthew, Ramos Silvia B V, Laederach Alain
Abstract excerpt
RNA conformation plays a significant role in stability, ligand binding, transcription, and translation. Single nucleotide variants (SNVs) have the potential to disrupt specific structural elements because RNA folds in a sequence-specific manner. A riboSNitch is an element of RNA structure with a specific function that is disrupted by an SNV or a single nucleotide polymorphism (SNP; or polymorphism; SNVs occur...
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