A human 3' miR-499 mutation alters cardiac mRNA targeting and function.

doi:10.1161/CIRCRESAHA.111.260752

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Article

A human 3' miR-499 mutation alters cardiac mRNA targeting and function.

Circulation research - 30 Mar 2012

Dorn Gerald W, Matkovich Scot J, Eschenbacher William H, Zhang Yan

Abstract excerpt

RATIONALE: MyomiRs miR-499, miR-208a and miR-208b direct cardiac myosin gene expression. Sequence complementarity between miRs and their mRNA targets determines miR effects, but the functional consequences of human myomiR sequence variants are unknown. OBJECTIVE: To identify and investigate mutations in human myomiRs in order to better understand how and to what extent naturally-occurring sequence variation can...

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Identifiers

PMID: 22374132
DOI: 10.1161/CIRCRESAHA.111.260752
PMCID: PMC3320730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.