Article
Genetic variation at the long noncoding RNA H19 gene is associated with the risk of hypertrophic cardiomyopathy.
Epigenomics - 1 Jul 2018
Gómez Juan, Lorca Rebeca, Reguero Julián R, Martín María, Morís César, Alonso Belén, Iglesias Sara, Díaz-Molina Beatriz, Avanzas Pablo, Coto Eliecer
Abstract excerpt
AIM: The long noncoding RNA H19 and its host micro RNA miR-675 have been found deregulated in cardiac hypertrophy and heart failure tissues. Our aim was to investigate whether the H19 gene variants were associated with the risk of hypertrophic cardiomyopathy (HCM). PATIENTS & METHODS: We genotyped two H19 tag single nucleotide polymorphisms in 405 HCM patients and 550 controls, and sequenced this gene in 100...
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