Article

The Mutational Landscape of TP53 in Pakistani Cancer Cohorts: A Systematic Review and Proportion Meta-Analysis for Precision Oncology Targets

2026-07-21

Abstract excerpt

<title>Abstract</title> Background TP53 is the most frequently mutated tumor suppressor gene in human malignancies, with mutation rates exceeding 50% in multiple cancer types. While global mutational hotspots are well-characterized, population-specific spectra in South Asian cohorts remain underrepresented, limiting the development of regionally targeted precision therapeutics. Objective To systematically ch...

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Literature Corpus work: d12318f9-9769-58cc-ac4c-6f558c75ddd5
DOI: 10.21203/rs.3.rs-10135591/v2

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