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Frequencies of TP53 Germline Variations and Identification of Two Novel 3’UTR Variants in a Series of Head and Neck Cancer Cases

2021-09-13

Abstract excerpt

TP53 is a tumour suppressor gene. Its inactivation plays a significant role in the molecular pathology of cancers. TP53 germline mutations increase the risk of developing multiple primary cancers. However, the role of alterations in TP53 germline DNA in head and neck cancers (HNCs) is not well-established. HNCs comprise one of the most frequent cancers in South Asia. The present discovery study reports the investi...

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Literature Corpus work: 6db8c38d-e109-502d-ab01-2ba48087222c
DOI: 10.1101/2021.09.09.21263314

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Frequencies of <i>TP53</i> Germline Variations and Identification of Two Novel 3’UTR Variants in a Series of Head and Neck Cancer Cases

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