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Association of TP53 (rs1042522) and BRCA1 Gene Polymorphisms with the Pharmacokinetics of 5-Fluorouracil among Breast Cancer Patients in Southern Punjab, Pakistan: A Step Towards Precision Oncology

2026-08-10

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<title>Abstract</title> <p>Background Breast cancer is the most common malignancy among women in Pakistan accounting for about 40% of all female cancers, most of which present at advanced stage (II-III). 5-Fluorouracil (5-FU), a cornerstone cytotoxic agent administered as part of the FAC (5-FU, Adriamycin, Cyclophosphamide) regimen, exhibits up to 100-fold inter-individual pharmacokinetic (PK) variability, resul...

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Literature Corpus work
0ccf1995-a6fc-56af-bb13-6892bb4b3624
DOI
10.21203/rs.3.rs-10240004/v1
Open publication

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Association of TP53 (rs1042522) and BRCA1 Gene Polymorphisms with the Pharmacokinetics of 5-Fluorouracil among Breast Cancer Patients in Southern Punjab, Pakistan: A Step Towards Precision OncologyDOI 10.21203/rs.3.rs-10240004/v1
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