Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The comparison of cancer gene mutation frequencies in Chinese and U.S. patient populations.

Nature communications - 26 Sept 2022

Ma Fayang, Laster Kyle, Dong Zigang

Abstract excerpt

Knowing the mutation frequency of cancer genes in China is crucial for reducing the global health burden. We integrate the tumor epidemiological statistics with cancer gene mutation rates identified in 11,948 cancer patients to determine their weighted proportions within a Chinese cancer patient cohort. TP53 (51.4%), LRP1B (13.4%), PIK3CA (11.6%), KRAS (11.1%), EGFR (10.6%), and APC (10.5%) are identified as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to ErbB Receptors
Share to Genes, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Mutation Rate

Share to Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 36163440
DOI: 10.1038/s41467-022-33351-4
PMCID: PMC9512793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The comparison of cancer gene mutation frequencies in Chinese and U.S. patient populations.PMID 36163440Read ↗

A catalogue of missense and nonsense mutation abundances for the U.S. cancer patient populationSemantic proximity Read ↗

Gene mutation profiling in Chinese colorectal cancer patients and its association with clinicopathological characteristics and prognosis.Semantic proximity Read ↗

Somatic gene mutation signatures predict cancer type and prognosis in multiple cancers with pan-cancer 1000 gene panel.Semantic proximity Read ↗

Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer riskSemantic proximity Read ↗

Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large-Scale Genomic Analysis of 1094 Patients.Semantic proximity Read ↗

Landscape of somatic alterations in large-scale solid tumors from an Asian populationSemantic proximity Read ↗

Clinical and genomic features of Chinese lung cancer patients with germline mutations.Semantic proximity Read ↗

The co-mutation of EGFR and tumor-related genes leads to a worse prognosis and a higher level of tumor mutational burden in Chinese non-small cell lung cancer patientsSemantic proximity Read ↗

The significance of gene mutations across eight major cancer typesSemantic proximity Read ↗

Analysis of gene mutation spectrum and prevention and treatment of lung cancer patients in Qujing, Yunnan Province, ChinaSemantic proximity Read ↗

Characterization of Mutational Signatures in Tumors from a Large Chinese Population.Semantic proximity Read ↗

Prevalence and clinical impact of TP53 germline mutations in Chinese women with breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.