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Article

The NEDD4-USP13 axis facilitates autophagy via deubiquitinating PIK3C3

15 Mar 2020

Abstract excerpt

Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and progression. The activity of PIK3C3 is tightly regulated by multiple post-translational...

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PMID: 32174250
DOI: 10.1080/15548627.2020.1743071

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