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Article

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.

Traffic (Copenhagen, Denmark) - 1 Jan 2022

Lu Chung-Ling, Ortmeier Steven, Brudvig Jon, Moretti Tamara, Cain Jacob, Boyadjiev Simeon A, Weimer Jill M, Kim Jinoh

Abstract excerpt

SEC24 is mainly involved in cargo sorting during COPII vesicle assembly. There are four SEC24 paralogs (A-D) in vertebrates, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mutations in SEC24D cause osteogenesis imperfecta with craniofacial dysplasia in humans. sec24d mutant fish also recapitulate the phenotypes. Consistent with the skeletal phenotypes, the secretion of collagen was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34761479
DOI: 10.1111/tra.12826
PMCID: PMC8692420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.PMID 34761479Read ↗

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulumSemantic proximity Read ↗

Sec24D-Dependent Transport of Extracellular Matrix Proteins Is Required for Zebrafish Skeletal MorphogenesisSemantic proximity Read ↗

Mutations in SEC24D, encoding a component of the COPII machinery, cause a syndromic form of osteogenesis imperfecta.Semantic proximity Read ↗

Bi-allelic mutation in SEC16B alters collagen trafficking and increases ER stress.Semantic proximity Read ↗

Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion.Semantic proximity Read ↗

Elucidating the impact of a synonymous SEC24D variant on aberrant splicing in a patient with cole-carpenter syndrome 2.Semantic proximity Read ↗

Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation.Semantic proximity Read ↗

The Sec domain protein Scfd1 facilitates trafficking of ECM components during chondrogenesis.Semantic proximity Read ↗

SURO-2/TMEM39 Facilitates Collagen Secretion through the Formation of Large COPII VesiclesSemantic proximity Read ↗

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivoSemantic proximity Read ↗

Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking PathwaySemantic proximity Read ↗

Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking.Semantic proximity Read ↗

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