Article

A Centenarian Single Nucleotide Polymorphism in collagen gene COL25A1 promotes longevity in C. elegans

2025-04-29

Abstract excerpt

<title>Abstract</title> <p>Before human genome sequencing, a genome-wide study of sibling centenarian pairs identified a longevity-associated locus on chromosome 4. Here, we mapped the genes in this locus and identified a collagen gene, <italic>COL25A1.</italic>Introducing an SNP linked to longevity that changes a serine predicted to be phosphorylated to leucine in <italic>COL25A1</italic>, into <italic>col-99</i...

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Literature Corpus work: 27b1a1fa-662f-5d2b-99f6-a42a684f7fd6
DOI: 10.21203/rs.3.rs-6035585/v1

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