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Article

Coordinated evolution of the hepatitis C virus.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 2008

Campo D S, Dimitrova Z, Mitchell R J, Lara J, Khudyakov Y

Abstract excerpt

Hepatitis C virus is a genetically heterogeneous RNA virus that is a major cause of liver disease worldwide. Here, we show that, despite its extensive heterogeneity, the evolution of hepatitis C virus is primarily shaped by negative selection and that numerous coordinated substitutions in the polyprotein can be organized into a scale-free network whose degree of connections between sites follows a power-law...

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Identifiers

PMID: 18621679
DOI: 10.1073/pnas.0801774105
PMCID: PMC2474538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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