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Article

Electrostatic state of the cytoplasmic domain influences inactivation at the selectivity filter of the KcsA potassium channel.

Biochimica et biophysica acta. Biomembranes - 1 Jan 2019

Hirano Minako, Ide Toru

Abstract excerpt

KcsA is a proton-activated K+ channel that is regulated at two gates: an activation gate located in the inner entrance of the pore and an inactivation gate at the selectivity filter. Previously, we revealed that the cytoplasmic domain (CPD) of KcsA senses proton and that electrostatic changes of the CPD influences the opening and closing of the activation gate. However, our previous studies did not reveal the...

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Identifiers

PMID: 30053405
DOI: 10.1016/j.bbamem.2018.07.011

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CPD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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