Article

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

2026-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Gene dosage imbalance resulting from an extra copy of human chromosome 21 (Hsa21) contributes to numerous clinical features in Down syndrome (DS). While dysregulated metabolism has long been noted in DS, the underlying cause is poorly understood and vastly understudied. To fill this critical knowledge gap, we conducted a comprehensive metabolic analysis of Dp(16)1Yey/+ mice (abbreviated Dp16), a...

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Literature Corpus work: d0c303dd-3f1f-5b9b-b715-3cd87561a424
DOI: 10.64898/2026.01.13.699318

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