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Article

Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice.

G3 (Bethesda, Md.) - 6 May 2026

Sloan Kourtney, Piner Kristina M, Kandedura Arachchige Pathum Randunu Nawarathna, Goodlett Charles R, Herault Yann, Olbricht Gayla R, Wallace Joseph M, Roper Randall J

Abstract excerpt

Down syndrome (DS) is caused by the triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency (low bone mineral density) and altered bone development. DS mouse models recapitulate these deficits, including sexual dimorphism in long bone alterations. Historically, Ts65Dn mice provided much of the insight behind DS-related skeletal deficits with ∼100 trisomic orthologous genes, but there are...

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Identifiers

PMID: 41788027
DOI: 10.1093/g3journal/jkag056
PMCID: PMC13270334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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