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Article

Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice.

Disease models & mechanisms - 1 Apr 2023

Sloan Kourtney, Thomas Jared, Blackwell Matthew, Voisard Deanna, Lana-Elola Eva, Watson-Scales Sheona, Roper Daniel L, Wallace Joseph M, Fisher Elizabeth M C, Tybulewicz Victor L J, Roper Randall J

Abstract excerpt

Down syndrome (DS) phenotypes result from triplicated genes, but the effects of three copy genes are not well known. A mouse mapping panel genetically dissecting human chromosome 21 (Hsa21) syntenic regions was used to investigate the contributions and interactions of triplicated Hsa21 orthologous genes on mouse chromosome 16 (Mmu16) on skeletal phenotypes. Skeletal structure and mechanical properties were...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genomic variations and chromosomal abnormalities

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Identifiers

PMID: 36939025
DOI: 10.1242/dmm.049927
PMCID: PMC10163323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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