Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.

doi:10.1242/dmm.049157

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Article

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.

Disease models & mechanisms - 1 Oct 2021

Lana-Elola Eva, Cater Heather, Watson-Scales Sheona, Greenaway Simon, Müller-Winkler Jennifer, Gibbins Dorota, Nemes Mihaela, Slender Amy, Hough Tertius, Keskivali-Bond Piia, Scudamore Cheryl L, Herbert Eleanor, Banks Gareth T, Mobbs Helene, Canonica Tara, Tosh Justin, Noy Suzanna, Llorian Miriam, Nolan Patrick M, Griffin Julian L, Good Mark, Simon Michelle, Mallon Ann-Marie, Wells Sara, Fisher Elizabeth M C, Tybulewicz Victor L J

Abstract excerpt

Down syndrome (DS), trisomy 21, results in many complex phenotypes including cognitive deficits, heart defects and craniofacial alterations. Phenotypes arise from an extra copy of human chromosome 21 (Hsa21) genes. However, these dosage-sensitive causative genes remain unknown. Animal models enable identification of genes and pathological mechanisms. The Dp1Tyb mouse model of DS has an extra copy of 63% of...

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PMID: 34477842
DOI: 10.1242/dmm.049157
PMCID: PMC8543064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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