Article

Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice

2025-02-01

Abstract excerpt

Down syndrome (DS) is caused by the triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency and altered bone development. DS mouse models recapitulate these deficits, including sexual dimorphism in long bone alterations. Historically, Ts65Dn mice provided much of the insight behind DS-related skeletal deficits with ∼100 trisomic orthologous genes, but there are concerns about genetic fidel...

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Literature Corpus work: 6f6fe745-b04c-5013-9616-e6dce0c6a925
DOI: 10.1101/2025.01.31.635850

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