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Article

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

15 Jan 2016

Abstract excerpt

Genes encoding human β-type globin undergo a developmental switch from embryonic to fetal to adult-type expression. Mutations in the adult form cause inherited hemoglobinopathies or globin disorders, including sickle cell disease and thalassemia. Some experimental results have suggested that these diseases could be treated by induction of fetal-type hemoglobin (HbF). However, the mechanisms that repress HbF in...

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PMID: 26816381
DOI: 10.1126/science.aad3312

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Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobinPMID 26816381Read ↗

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