Article

Non-redundant role of the α3 isoform of Na <sup>+</sup> ,K <sup>+</sup> -ATPase in neuronal excitability and spiking dynamics

2025-10-26

Abstract excerpt

The Na + ,K + -ATPase (NKA) plays a fundamental role in neuronal excitability by maintaining ionic gradients and contributing to electrogenic resting currents. Among its isoforms, the neuron-specific α3 subunit exhibits a uniquely low affinity for intracellular Na + , weak voltage dependence, and slightly reduced ATP sensitivity compared to the ubiquitous α1 . Although mutations in ATP1A3 are known to cause...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d08ec364-5a39-5143-b4c7-04d3300e1615
DOI: 10.1101/2025.10.24.684230

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-redundant role of the α3 isoform of Na <sup>+</sup> ,K <sup>+</sup> -ATPase in neuronal excitability and spiking dynamicsDOI 10.1101/2025.10.24.684230Read

The electrogenicity of the Na <sup>+</sup> /K <sup>+</sup> -ATPase poses challenges for computation in highly active spiking cellsSemantic proximity Read

Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal EnduranceSemantic proximity Read

Neurological disease mutations of α3 Na+,K+-ATPase: Structural and functional perspectives and rescue of compromised function.Semantic proximity Read

Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump.Semantic proximity Read

Active Conformations of Neuronal Na <sup>+</sup> ,K <sup>+</sup> -ATPase isoforms and a Disease-Causing MutantSemantic proximity Read

Mechanisms underlying the distinct K+ dependencies of periodic paralysis.Semantic proximity Read

Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.Semantic proximity Read

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.Semantic proximity Read

Impaired stretch modulation in potentially lethal cardiac sodium channel mutants.Semantic proximity Read

A global defect in scaling relationship between electrical activity and availability of muscle sodium channels in hyperkalemic periodic paralysis.Semantic proximity Read

Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.Semantic proximity Read

Computational modelling of natural cell-to-cell heterogeneity reveals key parameters that control the diversity of human pancreatic islet β-cell excitability in response to glucoseSemantic proximity Read