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Article

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Jan 2009

Morth J Preben, Poulsen Hanne, Toustrup-Jensen Mads S, Schack Vivien Rodacker, Egebjerg Jan, Andersen Jens Peter, Vilsen Bente, Nissen Poul

Abstract excerpt

The Na+,K+-ATPase transforms the energy of ATP to the maintenance of steep electrochemical gradients for sodium and potassium across the plasma membrane. This activity is tissue specific, in particular due to variations in the expressions of the alpha subunit isoforms one through four. Several mutations in alpha2 and 3 have been identified that link the specific function of the Na+,K+-ATPase to the...

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Identifiers

PMID: 18957371
DOI: 10.1098/rstb.2008.0201
PMCID: PMC2674101

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