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Article

Impaired stretch modulation in potentially lethal cardiac sodium channel mutants.

Channels (Austin, Tex.) - 1 Jan 2000

Banderali Umberto, Juranka Peter F, Clark Robert B, Giles Wayne R, Morris Catherine E

Abstract excerpt

The presence of two slowly inactivating mutants of the cardiac sodium channel (hNa(V)1.5), R1623Q and R1626P, associate with sporadic Long-QT3 (LQT3) syndrome, and may contribute to ventricular tachyarrhythmias and/or lethal ventricular disturbances. Cardiac mechanoelectric feedback is considered...

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Source

Identifiers

PMID: 20090423
DOI: 10.4161/chan.4.1.10260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20090423-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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