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Article

Mechanisms underlying the distinct K+ dependencies of periodic paralysis.

The Journal of general physiology - 5 May 2025

Foy Brent D, Dupont Chris, Walker Phillip V, Denman Kirsten, Engisch Kathrin L, Rich Mark M

Abstract excerpt

Patients with periodic paralysis have attacks of weakness precipitated by depolarization of muscle. Each form of periodic paralysis is associated with unique changes in serum K+ during attacks of weakness. In hypokalemic periodic paralysis (hypoKPP), the mutation-induced gating pore current causes weakness associated with low serum K+. In hyperkalemic periodic paralysis (hyperKPP), mutations increase a...

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Identifiers

PMID: 39903205
DOI: 10.1085/jgp.202413610
PMCID: PMC11792889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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