Article

The electrogenicity of the Na <sup>+</sup> /K <sup>+</sup> -ATPase poses challenges for computation in highly active spiking cells

2024-09-24

Abstract excerpt

1 <h4>Summary</h4> The evolution of the Na + /K + -ATPase laid the foundation for ion homeostasis and electrical signalling. While not required for restoration of ionic gradients, the electrogenicity of the pump (resulting from its 3:2 stoichiometry) is useful to prevent runaway activity. As we show here, electrogenicity could also come with disadvantageous side effects: (1) an activity-dependent shift in a cel...

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Literature Corpus work: c05a3311-b043-59d5-857f-b74346f7ba8c
DOI: 10.1101/2024.09.24.614486

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