Article

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs

2020-10-23

Abstract excerpt

The COVID-19 pandemic has caused over one million deaths thus far. There is an urgent need for the development of specific viral therapeutics and a vaccine. SARS-CoV-2 nucleocapsid (N) protein is highly expressed upon infection and is essential for viral replication, making it a promising target for both antiviral drug and vaccine development. Here, starting from a functional proteomics workflow, we initially cata...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94a8cc16-de14-51a6-afdf-cde3ea4b9a2f
DOI: 10.1101/2020.10.23.342113

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAsDOI 10.1101/2020.10.23.342113Read

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress responseSemantic proximity Read

Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 InfectionSemantic proximity Read

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replicationSemantic proximity Read

Pro-Viral and Anti-Viral Roles of the RNA-Binding Protein G3BP1Semantic proximity Read

Atlas of interactions between SARS-CoV-2 macromolecules and host proteinsSemantic proximity Read

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilitiesSemantic proximity Read

SARS-CoV-2 Nucleocapsid Protein Targets a Conserved Surface Groove of the NTF2-like Domain of G3BP1.Semantic proximity Read

Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replicationSemantic proximity Read

Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 VirusSemantic proximity Read

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replicationSemantic proximity Read

Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactionsSemantic proximity Read

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translationSemantic proximity Read