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Lipid Droplets Are Beneficial for Rabies Virus Replication by Facilitating Viral Budding

10 Nov 2021

Abstract excerpt

Lipid droplets have been proven to play an important role in viral infections, but their role in RABV infection has not yet been elaborated. Here, we find that RABV infection upregulates the generation of LDs by enhancing the expression of N-myc downstream regulated gene-1 (NDRG1). Then NDRG1 elevated cellular triglycerides synthesis by increasing the activity of diacylglycerol acyltransferase 1/2 (DGAT1/2),...

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PMID: 34757839
DOI: 10.1128/jvi.01473-21

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