Article
Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation.
Molecular cell - 11 Apr 2013
Dou Zhixun, Pan Ji-An, Dbouk Hashem A, Ballou Lisa M, DeLeon Jennifer L, Fan Yongjun, Chen Juei-Suei, Liang Zhimin, Li Guangpu, Backer Jonathan M, Lin Richard Z, Zong Wei-Xing
Abstract excerpt
Autophagy is an evolutionarily conserved membrane trafficking process. Induction of autophagy in response to nutrient limitation or cellular stress occurs by similar mechanisms in organisms from yeast to mammals. Unlike yeast, metazoan cells rely more on growth factor signaling for a wide variety of cellular activities including nutrient uptake. How growth factor availability regulates autophagy is poorly...
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