Article

Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation

2024-04-13

Abstract excerpt

The mitochondrial-rich renal tubule cells are key regulators of blood homeostasis via excretion and reabsorption of metabolic waste. With age, tubules are subject to increasing mitochondrial dysfunction and declining nicotinamide adenine dinucleotide (NAD + ) levels, both hampering ATP production efficiency. We tested two mitochondrial interventions in young (6-mo) and aged (26-mo) adult male mice: (ELAM), a tetr...

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Literature Corpus work: d05d73f6-c522-53fe-be1b-48004cc4c98c
DOI: 10.1101/2024.04.09.588624

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