Article

From GWAS to drug: A framework for drug candidate prioritisation using a gene expression signature matching approach

2026-04-24

Abstract excerpt

Drug targets supported by human genetic evidence have significantly higher approval rates, making genome-wide association studies a valuable resource for drug candidate prioritisation. Transcriptome-wide association study signature-matching is an emerging in silico approach that integrates GWAS data with expression quantitative trait loci to generate a disease gene expression signature, which is then compared aga...

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Literature Corpus work: d0596b81-c946-5622-a7ec-13b925013c10
DOI: 10.64898/2026.04.22.26349470

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