Article
Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.
Genome medicine - 20 Jan 2025
Halu Arda, Chelvanambi Sarvesh, Decano Julius L, Matamalas Joan T, Whelan Mary, Asano Takaharu, Kalicharran Namitra, Singh Sasha A, Loscalzo Joseph, Aikawa Masanori
Abstract excerpt
BACKGROUND: Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. Here, we present a network-based statistical approach, Pathopticon, that uses...
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