Article

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

2024-04-22

Abstract excerpt

The continuous evolution of SARS-CoV-2, particularly the emergence of the BA.2.86/JN.1 lineage replacing XBB lineages, necessitates re-evaluation of current vaccine compositions. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposures, emphasizing the need for JN.1-lineage-based boosters. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-...

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Literature Corpus work: 351bb574-1b1b-56ce-84e7-751674db8428
DOI: 10.1101/2024.04.19.590276

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