Article
MorphoITH: a framework for deconvolving intra-tumor heterogeneity using tissue morphology.
Genome medicine - 19 Sept 2025
Nielsen Aleksandra Weronika, Manoochehri Hafez Eslami, Zhong Hua, Panwar Vandana, Jarmale Vipul, Jasti Jay, Nourani Mehrdad, Rakheja Dinesh, Brugarolas James, Kapur Payal, Rajaram Satwik
Abstract excerpt
BACKGROUND: Tumor evolution, driven by the emergence of genetically and epigenetically distinct subclones, enables cancers to adapt to selective pressures and become more aggressive, posing a major challenge in oncology. Multi-regional sequencing has been the primary means of studying tumor evolution and the resultant intra-tumor heterogeneity (ITH), but its high cost, resource-intensiveness, and limited...
Topics
Join the communities discussing this publication.