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Eradicating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

2021-05-20

Abstract excerpt

<title>Abstract</title> <p>Leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) are quiescent, insensitive to BCR-ABL1 tyrosine kinase inhibitors (TKIs) and responsible for CML relapse. Therefore, eradicating quiescent CML LSCs is a major goal in CML therapy. Here, using a novel G0 marker (G0M), we narrowed down CML LSCs as G0M- and CD27- double positive cells among the conventional CML LSCs. Whole transc...

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Literature Corpus work
d0246d5c-52ba-5338-b609-527c90c45183
DOI
10.21203/rs.3.rs-449398/v1
Open publication

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Eradicating chronic myeloid leukemia stem cells by IRAK1/4 inhibitorsDOI 10.21203/rs.3.rs-449398/v1
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