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Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort?

30 Jun 2021

Abstract excerpt

Chronic myeloid leukemia (CML) is a classical example of stem cell cancer since it arises in a multipotent hematopoietic stem cell upon the acquisition of the t(9;22) chromosomal translocation, that converts it into a leukemic stem cell (LSC). The resulting BCR-ABL1 fusion gene encodes a deregulated tyrosine kinase that is recognized as the disease driver. Therapy with tyrosine kinase inhibitors (TKIs) eliminates...

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PMID: 34209376
DOI: 10.3390/ijms22137093

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