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Article

Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel.

Archives of biochemistry and biophysics - 15 Aug 2016

Cao Yipeng, Wu Xue, Wang Xinyu, Sun Haiying, Lee Imshik

Abstract excerpt

Sarcolipin (SLN), an important membrane protein expressed in the sarcoplasmic reticulum (SR), regulates muscle contractions in cardiac and skeletal muscle. The phosphorylation at amino acid Thr5 of the SLN protein modulates the amount of Ca(2+) that passes through the SR. Using molecular dynamics simulation, we evaluated the phosphorylation at Thr5 of pentameric SLN (phospho-SLN) channel's energy barrier and pore...

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Identifiers

PMID: 27378083
DOI: 10.1016/j.abb.2016.06.016

Genes

SLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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