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Article

Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Oct 2024

Rajebhosale Prithviraj, Jone Alice, Johnson Kory R, Hofland Rohan, Palarpalar Camille, Khan Samara, Role Lorna W, Talmage David A

Abstract excerpt

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by γ-secretase resulting in...

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Identifiers

PMID: 39214704
DOI: 10.1523/JNEUROSCI.0063-24.2024
PMCID: PMC11502234

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