Article

Neuregulin1 nuclear signaling influences adult neurogenesis and regulates a schizophrenia susceptibility gene network within the mouse dentate gyrus

2022-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Neuregulin1 (Nrg1) signaling is critical for aspects of neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bi-directional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: 1. local axonal PI3K-AKT signaling, and 2. cleavage by...

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Literature Corpus work: fc70e130-507a-5c35-a2e7-aafe1f7d9e2a
DOI: 10.1101/2022.08.10.503469

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