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Article

Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling.

Life science alliance - 1 Jul 2025

Rajebhosale Prithviraj, Jiang Li, Ressa Haylee J, Johnson Kory R, Desai Niraj S, Jone Alice, Role Lorna W, Talmage David A

Abstract excerpt

Neuronal heterogeneity is a defining feature of the developing mammalian brain, but the mechanisms regulating the diversification of closely related cell types remain elusive. Here, we investigated granule cell (GC) subtype composition in the dentate gyrus (DG) and the influence of a psychosis-associated V321L mutation in Neuregulin1 (Nrg1). Using morphoelectric characterization, single-nucleus gene expression,...

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PMID: 40280713
DOI: 10.26508/lsa.202403169
PMCID: PMC12032840

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GC

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