Article

Decoding stimulus-specific regulation of promoter activity of p53 target genes

2025-04-15

Abstract excerpt

The tumor suppressor p53 plays a crucial role in maintaining genome integrity in response to exogenous or endogenous stresses. The dynamics of p53 activation are stimulus- and cell type- dependent and regulate cell fate. Acting as a transcription factor, p53 induces the expression of target genes involved in apoptosis, cell cycle arrest and DNA repair. However, transcription is not a deterministic process, but rat...

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Literature Corpus work: d007da09-ee08-5973-a6b1-5816c8007170
DOI: 10.1101/2025.04.09.647556

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