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Determinants of p53 DNA binding, gene regulation, and cell fate decisions

29 Jun 2024

Abstract excerpt

The extent to which transcription factors read and respond to specific information content within short DNA sequences remains an important question that the tumor suppressor p53 is helping us answer. We discuss recent insights into how local information content at p53 binding sites might control modes of p53 target gene activation and cell fate decisions. Significant prior work has yielded data supporting two...

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PMID: 38951700
DOI: 10.1038/s41418-024-01326-1

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