Article

Polygenic basis and biomedical consequences of telomere length variation

2021-03-24

Abstract excerpt

Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence 1 . Here we characterize the genetic architecture of naturally-occurring variation in leucocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized participants in UK Biobank 2 . We identified 197 independent sentinel variants associated with LTL at 13...

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Literature Corpus work: c44e553a-6a96-58d5-8e76-21b5437d37e5
DOI: 10.1101/2021.03.23.21253516

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