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Article

Genomic, phenomic and geographic associations of leukocyte telomere length in the United States.

Nature genetics - 1 Apr 2026

Nakao Tetsushi, Koyama Satoshi, Truong Buu, Uddin Md Mesbah, Misra Anika, Patel Aniruddh P, Bhatnagar Aarushi, Viscosi Victoria, Vlasschaert Caitlyn, Bick Alexander G, Nelson Christopher P, Codd Veryan, Samani Nilesh J, Hornsby Whitney, Ellinor Patrick T, Natarajan Pradeep

Abstract excerpt

Leukocyte telomere length (LTL) is associated with multiple conditions, including cardiovascular diseases and neoplasms, yet their differential associations across diverse individuals are largely unknown. We estimated LTL from blood-derived whole-genome sequences in the All of Us research program (n = 242,494) with diverse ancestries across the USA. LTL was associated with lifestyle, socioeconomic status,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41896353
DOI: 10.1038/s41588-026-02567-1
PMCID: PMC13083252

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