Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic basis and biomedical consequences of telomere length variation

1 Oct 2021

Abstract excerpt

Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized UK Biobank participants. We identified 197 independent sentinel variants associated with LTL at 138...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34611362
DOI: 10.1038/s41588-021-00944-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic basis and biomedical consequences of telomere length variationPMID 34611362Read ↗

Polygenic basis and biomedical consequences of telomere length variationSemantic proximity Read ↗

Genomic, phenomic and geographic associations of leukocyte telomere length in the United States.Semantic proximity Read ↗

Genomic, phenomic, and geographic associations of leukocyte telomere length in the United StatesSemantic proximity Read ↗

Genetic and clinical determinants of telomere lengthSemantic proximity Read ↗

Breaking down causes, consequences, and mediating effects of telomere length variation on human healthSemantic proximity Read ↗

Contribution of leukocyte telomere length to major cardiovascular diseases onset: phenotypic and genetic insights from a large-scale genome-wide cross-trait analysisSemantic proximity Read ↗

Telomere length and common disease: study design and analytical challengesSemantic proximity Read ↗

Contribution of leukocyte telomere length to major cardiovascular diseases onset: insights from a large-scale genome-wide cross-trait analysisSemantic proximity Read ↗

Contribution of leukocyte telomere length to major cardiovascular diseases onset: phenotypic and genetic insights from a large-scale genome-wide cross-trait analysisSemantic proximity Read ↗

Unraveling the causal genes and transcriptomic determinants of human telomere lengthSemantic proximity Read ↗

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequencesSemantic proximity Read ↗

Telomere length measurement as a clinical biomarker of aging and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.