Article

Human hepatic tryptophan 2,3-dioxygenase ubiquitin-dependent protein degradation: The critical role of its exosite as the molecular lynchpin of its substrate-mediated protein stabilization

2019-10-04

Abstract excerpt

Hepatic tryptophan 2,3-dioxygenase (TDO) is a cytoplasmic homotetrameric hemoprotein and the rate-limiting enzyme in the irreversible degradation of the essential amino acid L -tryptophan ( L-Trp ) to N-formylkynurenine, thus controlling the flux of L -Trp into its serotonergic and kynureninic/NAD pathways. TDO has long been recognized to be substrate-inducible via protein stabilization, but the molecular mecha...

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Literature Corpus work: d002a20b-334d-527c-bae3-d27be19af8c6
DOI: 10.1101/793380

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